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*Correspondence: Wanqing Liu, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, Room 224B, West Lafayette, IN 47907, USA e-mail: [email protected] This article was submitted to Pharmacogenetics and Pharmacogenomics, a section of the journal Frontiers in Genetics

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Based on available data, a minimum trial period of 4-8 weeks at 500-1,000 mg/day is typical before evaluating results